THE HER2-DIRECTED ANTIBODY-DRUG CONJUGATE DHES0815A IN ADVANCED AND/OR METASTATIC BREAST CANCER: PRECLINICAL CHARACTERIZATION AND PHASE 1 TRIAL RESULTS

Abstract Approved antibody-drug conjugates (ADCs) for HER2-positive breast cancer include trastuzumab emtansine and trastuzumab deruxtecan.To develop a differentiated HER2 ADC, we chose an antibody that does not compete with trastuzumab or pertuzumab for binding, conjugated to a reduced potency PBD (pyrrolobenzodiazepine) dimer payload.PBDs are pot

Common konjac flour, especially of low grade, is a waste material produced in large quantities during purification of konjac glucomannan (KGM).It contains impurities, particularly oxalate salts, which irritate and may cause kidney stones.Konjac here flour has glucomannan as a main component.Glucomannan is characterized by low crystallinity, high th

In addition to the deep global economic recession, entrepreneurs are currently facing many challenges due to the health crisis caused by COVID-19, which has increased the rate of biomat for sale unemployment in Ecuador.According to the report of the Global Entrepreneurship Monitor in the region, Ecuador is the country with the highest rates of entr